Scientific Projects

Under Valentyn Chebanov’s management

Title: Polypharmacophoric organic compounds based on peptidomimetics and fused benzodiazepines
Term: 2020 – 2022
Support: National Research Foundation of Ukraine
Development of new effective synthetic approaches to pharmaco-promising structurally complex organic compounds based on a tandem combination of multicomponent and click-reactions using non-classical activation methods. Study of the features of the molecular structure, biological screening in silico, and study of the membranotropic effect of the obtained compounds.

Title: Creation of modern principles for obtaining and analysis of substances and components of materials of pharmaceutical purpose
Term: 2019 – 2021
Support: National Academy of Sciences of Ukraine
The main aim is creation of a complex of fundamental principles for modern synthesis, the structural and chemical analysis of compounds and materials for pharmaceutical purposes.

Title: Development of novel methods for synthesis and analysis of supramolecular complexes based on 1-methylcyclopropene and receptors of different origin for use in agro-industrial complex
Term: 2019 – 2021
Support: Competitive Project of National Academy of Sciences of Ukraine
The main aim is development of new methods for the synthesis and analysis of supramolecular complexes of 1-methylcyclopropene with some receptors (cyclodextrin, cucurbituril, etc.) to further creation of new agricultural preparations for fruit treatment and vegetable products to slow ripening and extend storage time.

Title: Creation of modern principles for obtaining and analysis of substances and materials for pharmacy
Term: 2018
Support: Competitive Project of National Academy of Sciences of Ukraine
The main aim of the project is creation of complex of fundamental principles for modern synthesis, novel structural and chemical analysis of substances and materials for pharmacy.

Title: Multicomponent isocyanide-based reactions of functionalized starting reagents and post-transformations of the compounds synthesized
Term: 2018
Support: Grant of President of Ukraine
The main goal of the project is elaborating the synthetic approaches for enlarging the molecular diversity of heterocyclic compounds by means of using purposefully functionalized starting reagents in isocyanide-based multicomponent reactions and carrying out the controlled post-cyclizations of the products obtained. Not only the fundamental problem of synthetic Organic Chemistry that is connected with the development of highly effective synthetic methods with controlled chemoselectivity within the concept of “ideal synthesis” and enlarging the molecular diversity of heterocyclic compounds but also the applied problems, namely, filling the chemical space with the series of new structurally-complex molecules with a well-proven structure for the future testing on the different types of biological activity will be solved.

Title: Development of methodology of “click”-chemistry for the creation of component for novel chalating materials
Term: 2017 – 2021
Support: National Academy of Sciences of Ukraine
The main aim of the project is development of methodology of “click”-chemistry for creation of organic compound having in their structure nitrogen containing heterocycles, fragments of natural molecular scaffolds and functional groups being able to be part of chelators.

Title: Development of methods of synthesis of novel chemotypes of drug-like nitrogen containing heterocyclic compounds
Term: 2016 – 2018
Support: National Academy of Sciences of Ukraine
The main aim of the project is the creation of fundamental principles for the development of novel methods of synthesis of drug-like heterocyclic compounds.

Title: Intensification of process of desoption and sorption separation of substances using ultrasonication
Term: 2016
Support: Grant of President of Ukraine
This project is devoted to the solution of one of the fundamental problem of modern chemistry concerned with the intensification of organic and inorganic substances sorption and desorption from different sorbents by means of ultrasound as an alternative energy source. The project is aimed at the investigation of the effect of ultrasound on the sorption and desorption processes involving various sorbents and intensification of these processes. In the frame of this project the effect of ultrasound on heavy metals desorption from the sorbents obtained after waste waters treatment, as well as on the separation and isolation of drug substances by the means of ion- exchange resins will be studied.

Title: Synthesis of N-rich Heterocyclic Chelators for Further Creation of Hybrid Organic-Inorganic Sorbents
Term: 2016
Support: DAAD
The main goal of the project is the solution of both the fundamental and applied problems of modern organic chemistry concerning elaboration of synthesis of novel types of N-rich heterocyclic chelators being able to form stable complexes with selected types of metal ions (Sr, Cs, Ce, Eu, etc.) and suitable to create organic-inorganic hybrid sorbents.

Title: Diversity-Oriented Synthesis of Novel Heterocycles by Combination of Doubner-type and Ugi Multicomponent Reaction
Term: 2014
Support: Research Council of Catholic University of Leuven
Combination of Doubner-type and Ugi multicomponent reactions for the development novel efficient approach to the heterocycles containing peptide-like substituents.

Title: Development of High-efficient Methods for Tuning Dispersion of Pharmaceutical Substances under Microwave and Ultrasonic Irradiation for Further Creation of Medicines with High Therapeutic Effect
Term:
2014 – 2016
Support: National Academy of Sciences of Ukraine
The main aim of the project is the development of high-efficient and energy-saving methods for the obtaining medicines with specified dispersion with help of non-classical methods of activation.

Title: Development of High-efficient Methods for Tuning Functional Properties of Organic and Inorganic Materials with help of Microwave irradiation and Ultrasonication 
Term: 2012 – 2013
Support: National Academy of Sciences of Ukraine
The main aim of the project is development of controlled methods for synthesis and crystallization of semi-conducting materials of A2B6 type and pharmaceutical substances with improved functional properties

Title: Development of Up-to-date Materials for Selective Sorption and Extraction of Radionuclides and Heavy Metals from Water of Different Origin
Term: 2012 – 2016
Support: National Academy of Sciences of Ukraine
The main aim of the project is development of novel high-efficient materials for sorption and extraction on the basis of organic and inorganic compounds for the selective withdrawal of radionuclides and heavy metals from water of different origin.

Title: Chemical and Analytic Support for Security Monitoring of Chemicals in Accordance with EU Requirements
Term: 2012
Support: State Agency for Science, Innovations and Informatization 
The aim of this project is the realization of measures relating creation of scientific and technological bases as well as methodological support of functioning of analytic centers for certification of industrial outputs in accordance with EU requirements.

Title: Tuning Selectivity of Multicomponent Heterocyclizations of Aminoazoles, Pyruvic Acid and Salicylic Aldehydes for Synthesis of Molecular Diverse Azoloazine Systems
Term: 2012
Support: DAAD
The main goal of the project is further development of strategy of the tuning selectivity of multicomponent reactions of aminoazoles, CH-acids and carbonyl compounds for selective formation of azoloazine heterocycles with high degree of molecular diversity.

Title: Multicomponent Heterocyclizations with Controlled Chemoselectivity for Synthesis of Azoloazine Systems with Ability to Form Metal Complexes
Term: 2012
Support: Grant of President of Ukraine
The main task of the project is further development of strategy of the tuning selectivity of multicomponent reactions of aminoazoles, CH-acids and carbonyl compounds for selective formation of azoloazine heterocycles with high degree of molecular diversity, including compounds being able to form complexes with metals.

Title: Tuning Selectivity of Multicomponent Reactions Involving Pyruvic Acid Derivatives
Term: 2008 – 2009
Support: Kharkiv State Administration
The project is devoted to the study of multicomponent heterocyclizations of pyruvic acids with aminoazoles, determination of their general laws, development of novel selective preparative methods for the synthesis of fused pyridine and pyrimidine carboxylic acids.

Title: Development of Pilot Installation and Implementation into Industry of Vacuum Microwave Dryer with 500 L Chamber (Principle manager – Prof. V.P. Semynozhenko)
Term: 2008
Support: National Academy of Sciences of Ukraine
The innovative project is concerned with final stages of development and manufacturing of pilot installation of vacuum microwave dryer with 500 L chamber, its testing and implementation into industry. Industrial partner in this project is “VIVA Ltd” (Donetsk, Ukraine)

Title: Synthesis of Binary Inorganic Oxides in Microwave Field (Principle manager – Dr. A.Yu. Voloshko)
Term: 2008
Support: National Academy of Sciences of Ukraine
The project is devoted to the development of new efficient and power-saving technologies of synthesis of binary inorganic oxides under microwave irradiation. The main attention of researchers is focused on tungstates of cadmium (CdWO4), zink (ZnWO4) and lead (PbWO4) which are raw materials for growing of scintillating single crystals.

Title: An Investigation of New Microwave-assisted Three-component Reaction of Cyclic 1,3-Diketones, Aldehydes and aminoazoles
Term: 2007
Support: DAAD
The main goal of the project is to study new microwave-assisted multicomponent reaction of cyclic 1,3-diketones, aldehydes and aminoazoles leading to diketone ring opening and formation of quinolizinones instead of “classical” Hantzsch products.

Title: Study of Multicomponent Solution-phase Synthesis of Pyridine and Pyrimidine Derivatives Based on Reaction of Pyruvic Acid with Aldehydes and Some Binucleophilic Reagents
Term: 2005 – 2006
Support: INTAS foundation
The main goal of the project is to study of multicomponent microwave assisted synthesis of partially hydrogenated pyridine and pyrimidine derivatives based on reaction of pyruvic acid with aldehydes and series of 1,3-binucleophilic reagents. In the course of the research work it was planned to establish a dependence of the direction of these reactions from process conditions to extend the field of application of pyruvic acid for synthesis of new heterocycles.

Title: Development of Novel Radiochromic Materials – Visual Indicators of Radioactivity
Term: 2003 – 2004
Support: National Academy of Sciences of Ukraine
The main aim of the project is development of indicators of radioactivity on the basis of plastic composites including photo- and radiochromic organic compounds.

Participation in Other Projects

Title: Functional materials for medical and biological purposes based on halogen-containing organic compounds.
Project manager – Prof. S.M. Desenko
Term: 2020
Support: National Academy of Sciences of Ukraine

Title: İmidazo[1,2-b]pirazol iskeleti türevi biyobelirteç adaylarının sentezi.
Project manager – Dr. Hasan Koyuncu
Term: 2019 – 2020
Support: TÜBİTAK

Title: Study of the structure of nitrogen-containing heterocycles with potential biological activity.
Project manager – Prof. S.M. Desenko
Term: 2019
Support: National Academy of Sciences of Ukraine

Title: Novel nanostructured multifunctional complexes of transition metals foe electronics and medicine
Project manager – Prof. V.O. Cheranovskii
Term: 2017 – 2019
Support: Ministry of Education and Science of Ukraine

Title: Development of innovation system for discovery and evaluation of biological activity of lead compounds for further elaboration on their base original drugs for correction of metabolic abnormalities associated with Type II diabetes.
Project manager – Prof. S.M. Desenko
Term: 2013 – 2014
Support: State Agency for Science, Innovations and Informatization

Title: Development of Novel Methods for Synthesis and Purification of Heterocyclic Compounds with Application of Non-classical Activation Methods
Project manager – Prof. S.M. Desenko
Term: 2013 – 2015
Support: National Academy of Sciences of Ukraine

Title: Development of New Methods of Synthesis of Nitrogen Containing Heterocycles by Multicomponent and Linear Reactions
Project manager – Prof. S.M. Desenko
Term: 2010 – 2012
Support: National Academy of Sciences of Ukraine

Title: Study of Novel Nitrogen Containing Heterocycles Based on Reactions of Unsaturated Carbonyls, their Synthetic Precursors and Equivalents
Project manager – Prof. S.M. Desenko
Term: 2007 – 2009
Support: National Academy of Sciences of Ukraine

Title: Study of New Ensembles of Partially Hydrogenated Heterocycles
Project manager – Prof. S.M. Desenko
Term: 2004 – 2006
Support: National Academy of Sciences of Ukraine

Title: Search for new photo- and Radiochromic Materials on the Basis of Bicyclic Derivatives of Aziridine
Project manager – Prof. S.M. Desenko
Term:2000 – 2002
Support:National Academy of Sciences of Ukraine